Understanding Type 2 Diabetes (Part1)
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T2DM develops due to a combination of two main factors: defective insulin secretion by pancreatic β-cells and the inability of insulin-sensitive tissues to respond to insulin properly.
♦ Imagine your body as a production factory.
- The cells in your body are the factory workers that need glucose as a raw material to generate energy.
- Insulin acts as the transport system that delivers glucose to these cells.
♦ In Type 2 Diabetes, this transport system (insulin) doesn't work properly.
- As a result, the factory workers (cells) can't get the glucose they need.
- Glucose starts to build up in the blood, leading to hyperglycemia.
- This dysfunction is called insulin resistance.
Complications arise if T2DM is not managed:
♦ Microvascular Complications
- Microvascular complications primarily involve small blood vessels.
- Chronic kidney disease and albuminuria (protein loss in urine) are common.
- Retinopathy, affecting the eyes, is a significant concern.
- Autonomic neuropathy, peripheral neuropathy, and erectile dysfunction can occur.
♦ Macrovascular Complications
- Macrovascular complications impact larger blood vessels.
- Coronary artery disease, angina, heart attacks, and heart failure are potential risks.
- Diabetic foot problems can lead to severe complications, including potential amputation.
WHY T2DM DEVELOPS?
- Genetics significantly influence T2DM risk, with many variants affecting insulin secretion and action.
- Obesity is a primary risk factor, leading to insulin resistance and T2DM.
- Daily exercise reduces T2DM risk by improving glucose sensitivity and reducing inflammation.
- These factors highlight the importance of a healthy lifestyle to prevent diabetes.
- Gut microbiota plays a role in T2DM, as gut dysbiosis can increase inflammation and insulin resistance, contributing to diabetes development.